Clinical Development in Dendritic Cell Based Immunotherapy
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چکیده
Dendritic cell have been recognized as most potent antigen presenting cells that capable of activating T cells against tumor antigen. Dendritic cells were first discovered by Steinman RM & Cohn ZA et al. [1]. He was awarded Nobel Prize in medicine in 2011 for discover of these novel cells. Expression of costimulatory molecule and ability to generate strong immune response differentiate it from B cell and macrophages [2,3]. Human dendritic cells mainly classified into two main categories viz plasmacytoid (pDCs) and myeloid (mDCs). PDCs mainly found in blood, bone marrow, thymus spleen etc however mDCs mainly found in peripheral blood [4].
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تاریخ انتشار 2016